GENERATING LITERATURE-BASED KNOWLEDGE DISCOVERIES IN LIFE SCIENCES USING RELATIONSHIP ASSOCIATIONS

Steven B. Kraines, Weisen Guo, Daisuke Hoshiyama, Haruo Mizutani, Toshihisa Takagi

2010

Abstract

The life sciences have been a pioneering discipline for the field of knowledge discovery, since the literature-based discoveries by Swanson three decades ago. Existing literature-based knowledge discovery techniques generally try to discover hitherto unknown associations of domain concepts based on associations that can be established from the literature. However, scientific facts are more often expressed as specific relationships between concepts and/or entities that have been established through scientific research. A pair of relationships that predicate the specific way in which one concept relates to another can be associated if one of the concepts from each relationship can be determined to be semantically equivalent; we call this a “relationship association”. Then, by making the same assumption of the transitivity of association used by Swanson and others, we can generate a hypothetical relationship association by combining two relationship associations that have been extracted from a knowledge base. Here we describe an algorithm for generating potential knowledge discoveries in the form of new relationship associations that are implied but not actually stated, and we test the algorithm against a corpus of almost 5000 relationship associations that we have extracted in previous work from 392 semantic graphs representing research articles from MEDLINE.

Paper Citation

in Harvard Style

Kraines S., Guo W., Hoshiyama D., Mizutani H. and Takagi T. (2010). GENERATING LITERATURE-BASED KNOWLEDGE DISCOVERIES IN LIFE SCIENCES USING RELATIONSHIP ASSOCIATIONS . In Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2010) ISBN 978-989-8425-28-7, pages 35-44. DOI: 10.5220/0003068100350044

in Bibtex Style

@conference{kdir10,
author={Steven B. Kraines and Weisen Guo and Daisuke Hoshiyama and Haruo Mizutani and Toshihisa Takagi},
title={GENERATING LITERATURE-BASED KNOWLEDGE DISCOVERIES IN LIFE SCIENCES USING RELATIONSHIP ASSOCIATIONS },
booktitle={Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2010)},
year={2010},
pages={35-44},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003068100350044},
isbn={978-989-8425-28-7},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2010)
TI - GENERATING LITERATURE-BASED KNOWLEDGE DISCOVERIES IN LIFE SCIENCES USING RELATIONSHIP ASSOCIATIONS
SN - 978-989-8425-28-7
AU - Kraines S.
AU - Guo W.
AU - Hoshiyama D.
AU - Mizutani H.
AU - Takagi T.
PY - 2010
SP - 35
EP - 44
DO - 10.5220/0003068100350044