Gene Ontology Analysis of Colorectal Cancer Biomarkers Probed with Affymetrix and Illumina Microarrays

Monika Simjanoska, Ana Madevska Bogdanova, Sasho Panov

2013

Abstract

Colorectal cancer is the fourth most common cause of death worldwide. Recently, many microarray experiments have been done to investigate the expression of the genes in the colorectal tissues and thus, to find the answers for its occurrence. Previously, we used experiments obtained from both Illumina and Affymetrix microarray platforms to analyze the gene expression in healthy and carcinogenic tissues. As a result we got specific sets of biomarkers that we used to build an accurate Bayesian diagnostic system. The high degree of classifier's sensitivity and specificity intrigued us to proceed with the research of the significant genes we discovered, the biomarkers. Therefore, in this paper we aim towards biomarkers identification and the functional groups they are associated with, i.e., we performed gene ontology analysis. Investigating the genes that control the colorectal carcinogenic tissue development is of central importance to the verification of the biomarkers' revealing method's validity. Moreover, we showed the importance of their participation in the prior distributions modeling, which is the key part for achieving an accurate Bayesian classification, regardless their strict disease and disorder association.

Paper Citation

in Harvard Style

Simjanoska M., Madevska Bogdanova A. and Panov S. (2013). Gene Ontology Analysis of Colorectal Cancer Biomarkers Probed with Affymetrix and Illumina Microarrays . In Proceedings of the 5th International Joint Conference on Computational Intelligence - Volume 1: NCTA, (IJCCI 2013) ISBN 978-989-8565-77-8, pages 396-406. DOI: 10.5220/0004554803960406

in Bibtex Style

@conference{ncta13,
author={Monika Simjanoska and Ana Madevska Bogdanova and Sasho Panov},
title={Gene Ontology Analysis of Colorectal Cancer Biomarkers Probed with Affymetrix and Illumina Microarrays},
booktitle={Proceedings of the 5th International Joint Conference on Computational Intelligence - Volume 1: NCTA, (IJCCI 2013)},
year={2013},
pages={396-406},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004554803960406},
isbn={978-989-8565-77-8},
}

in EndNote Style

TY - CONF
JO - Proceedings of the 5th International Joint Conference on Computational Intelligence - Volume 1: NCTA, (IJCCI 2013)
TI - Gene Ontology Analysis of Colorectal Cancer Biomarkers Probed with Affymetrix and Illumina Microarrays
SN - 978-989-8565-77-8
AU - Simjanoska M.
AU - Madevska Bogdanova A.
AU - Panov S.
PY - 2013
SP - 396
EP - 406
DO - 10.5220/0004554803960406