Analysis of Spontaneous MEG Activity in Mild Cognitive Impairment using the Wavelet Turbulence

Jesús Poza, Carlos Gómez, María García, Alberto Fernández, Roberto Hornero

2012

Abstract

Mild cognitive impairment (MCI) is usually considered a pre-clinical stage of Alzheimer’s disease (AD). An appropriate characterization of MCI is crucial to achieve an early diagnosis of AD. Over the last few years, much effort has been devoted to identifying new diagnostic tests; tough further research is still required. In this study, we analyzed the spontaneous magnetoencephalographic (MEG) activity from 18 MCI subjects and 27 healthy controls to characterize the irregularity patterns in MCI. For that purpose, the wavelet turbulence (WT) was calculated from the time-scale representation provided by the continuous wavelet transform (CWT). Our results revealed that the mean values and the standard deviation of WT for MCI subjects were significantly higher and lower (p < 0.05) than for controls, respectively. These findings support the notion that MCI is associated with a significant decrease in irregularity and variability when compared to normal aging. A Receiver Operating Characteristic (ROC) analysis with a leave-one-out cross-validation procedure was applied to assess the diagnostic ability of WT. We obtained an accuracy of 66.7% and an area under ROC curve of 0.704. We conclude that the WT extends the concept of irregularity and provides potential descriptors of spontaneous MEG activity in MCI.

Paper Citation

in Harvard Style

Poza J., Gómez C., García M., Fernández A. and Hornero R. (2012). Analysis of Spontaneous MEG Activity in Mild Cognitive Impairment using the Wavelet Turbulence . In Proceedings of the 4th International Joint Conference on Computational Intelligence - Volume 1: SSCN, (IJCCI 2012) ISBN 978-989-8565-33-4, pages 721-726. DOI: 10.5220/0004182107210726

in Bibtex Style

@conference{sscn12,
author={Jesús Poza and Carlos Gómez and María García and Alberto Fernández and Roberto Hornero},
title={Analysis of Spontaneous MEG Activity in Mild Cognitive Impairment using the Wavelet Turbulence},
booktitle={Proceedings of the 4th International Joint Conference on Computational Intelligence - Volume 1: SSCN, (IJCCI 2012)},
year={2012},
pages={721-726},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004182107210726},
isbn={978-989-8565-33-4},
}

in EndNote Style

TY - CONF
JO - Proceedings of the 4th International Joint Conference on Computational Intelligence - Volume 1: SSCN, (IJCCI 2012)
TI - Analysis of Spontaneous MEG Activity in Mild Cognitive Impairment using the Wavelet Turbulence
SN - 978-989-8565-33-4
AU - Poza J.
AU - Gómez C.
AU - García M.
AU - Fernández A.
AU - Hornero R.
PY - 2012
SP - 721
EP - 726
DO - 10.5220/0004182107210726