Semantic Interoperability Solution for Multicentric Breast Cancer Trials at the Integrate EU Project

Sergio Paraiso-Medina, David Perez-Rey, Raúl Alonso-Calvo, Brecht Claerhout, Kristof de Schepper, Philippe Hennebert, Jérôme Lhaut, Jasper Van Leeuwen, Anca Bucur

2013

Abstract

The introduction of –omic information within current clinical treatment is one of the main challenges to transfer the huge amount of genomic-based results. The number of potential translational clinical trials is therefore experiencing a dramatic increase, with the corresponding increment on patient variability. Such scenario requires a larger population to recruit a minimum set of patients that may involve multi-centric trials, with associated challenges on heterogeneous data integration. To ensure sustainability on clinical trial management, semantic interoperability is one of the main goals addressed by international initiatives such as the EU funded INTEGRATE project: “Driving Excellence in Integrative Cancer Research”. This paper describes the approach adopted within an international research initiative, providing a homogeneous platform to manage clinical information from patients on breast cancer clinical trials. Following the project “leitmotif” of reusing standards supported by a large community, we have developed a solution providing a common data model (i.e. HL7 RIM-based), a biomedical domain vocabulary (i.e. SNOMED) as core dataset and resources from the semantic web community adapted for the biomedical domain. After one year and a half of collaboration, the INTEGRATE consortium has been able to develop a solution providing the reasoning capabilities required to solve clinical trial patient recruitment. The next challenge will be to extend the current solution to support a cohort selection tool allowing prospective analysis and predictive modeling.

Paper Citation

in Harvard Style

Paraiso-Medina S., Perez-Rey D., Alonso-Calvo R., Claerhout B., de Schepper K., Hennebert P., Lhaut J., Van Leeuwen J. and Bucur A. (2013). Semantic Interoperability Solution for Multicentric Breast Cancer Trials at the Integrate EU Project . In Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2013) ISBN 978-989-8565-37-2, pages 34-41. DOI: 10.5220/0004223400340041

in Bibtex Style

@conference{healthinf13,
author={Sergio Paraiso-Medina and David Perez-Rey and Raúl Alonso-Calvo and Brecht Claerhout and Kristof de Schepper and Philippe Hennebert and Jérôme Lhaut and Jasper Van Leeuwen and Anca Bucur},
title={Semantic Interoperability Solution for Multicentric Breast Cancer Trials at the Integrate EU Project},
booktitle={Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2013)},
year={2013},
pages={34-41},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004223400340041},
isbn={978-989-8565-37-2},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2013)
TI - Semantic Interoperability Solution for Multicentric Breast Cancer Trials at the Integrate EU Project
SN - 978-989-8565-37-2
AU - Paraiso-Medina S.
AU - Perez-Rey D.
AU - Alonso-Calvo R.
AU - Claerhout B.
AU - de Schepper K.
AU - Hennebert P.
AU - Lhaut J.
AU - Van Leeuwen J.
AU - Bucur A.
PY - 2013
SP - 34
EP - 41
DO - 10.5220/0004223400340041