Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue

Mohammad Ali Moni, Pietro Liò, Luciano Milanesi

2013

Abstract

This paper focuses on the differences between S. aureus bacterial and HIV viral infection of the bone tissue. Both of these infections alters the RANK/RANKL/OPG signalling dynamics that regulates osteoblasts and osteoclasts behavior in bone remodelling. These infections rapidly lead to severe bone loss and it may even spread to other parts of the body. Since both HIV and osteomyelitis cause loss of bone mass, we focused on comparing the dynamics of these diseases by means of computational models. Firstly, we performed meta-analysis on the gene expression data of normal, HIV and osteomyelitis bone conditions and compare the effects of HIV and S. aureus infection. We mainly focused on RANKL/OPG signalling, the TNF and TNF receptor superfamilies and the NF-kB pathway. Using information from the gene expression data, we estimated parameters for a novel model of osteomyelitis. Then we develop another multi strain HIV ODE model incorporating the HAART therapy. Our ODE modelling aims at investigating the dynamics of the effects of osteomyelitis and HIV infection in bone remodelling.

Paper Citation

in Harvard Style

Ali Moni M., Liò P. and Milanesi L. (2013). Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 196-201. DOI: 10.5220/0004249801960201

in Bibtex Style

@conference{bioinformatics13,
author={Mohammad Ali Moni and Pietro Liò and Luciano Milanesi},
title={Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={196-201},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004249801960201},
isbn={978-989-8565-35-8},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Comparing Viral (HIV) and Bacterial (Staphylococcus aureus) Infection of the Bone Tissue
SN - 978-989-8565-35-8
AU - Ali Moni M.
AU - Liò P.
AU - Milanesi L.
PY - 2013
SP - 196
EP - 201
DO - 10.5220/0004249801960201