Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis

Peter Kupfer, Sebastian Vlaic, René Huber, Raimund W. Kinne, Reinhard Guthke

2013

Abstract

Since genetic and epigenetic factors are known to be involved in the pathogenesis of rheumatoid arthritis the search for key players in this disease is one of the most important challenges. For this purpose gene regulatory networks are one possibility to reveal underlying interactions for different stimuli. In this study we analyzed the cellular response of synovial fibroblasts to 4 different stimuli. We infered a gene regulatory network that is able to explain the observed data for stimulation by TNF-a, TGF-b1, IL-1 and PDGF-D simultaneously.

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in Harvard Style

Kupfer P., Vlaic S., Huber R., W. Kinne R. and Guthke R. (2013). Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 282-287. DOI: 10.5220/0004196402820287

in Bibtex Style

@conference{bioinformatics13,
author={Peter Kupfer and Sebastian Vlaic and René Huber and Raimund W. Kinne and Reinhard Guthke},
title={Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={282-287},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004196402820287},
isbn={978-989-8565-35-8},
}


in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Different Stimuli for Inference of Gene Regulatory Network in Rheumatoid Arthritis
SN - 978-989-8565-35-8
AU - Kupfer P.
AU - Vlaic S.
AU - Huber R.
AU - W. Kinne R.
AU - Guthke R.
PY - 2013
SP - 282
EP - 287
DO - 10.5220/0004196402820287