PROTEINS POCKETS ANALYSIS AND DESCRIPTION

Virginio Cantoni, Riccardo Gatti, Luca Lombardi

2010

Abstract

The development of computational techniques to guide the experimental processes is an important step for the determination of the protein functions. The purpose of the activity here described is the characterization of the active sites in protein surfaces and their quantitative representation. A few pocket parameters like volume, travel depth, mouth area and perimeter, amplitude parameters, interfacial area ratio, summit density and mean summit curvature are hierarchically accessible through a concavity tree that topologically represents the entire protein molecule. This structural representation is particularly useful for the evaluation of binding pockets, the comparison of the morphological similarity and the identification of potential ligand docking.

Paper Citation

in Harvard Style

Cantoni V., Gatti R. and Lombardi L. (2010). PROTEINS POCKETS ANALYSIS AND DESCRIPTION . In Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010) ISBN 978-989-674-019-1, pages 211-216. DOI: 10.5220/0002725302110216

in Bibtex Style

@conference{bioinformatics10,
author={Virginio Cantoni and Riccardo Gatti and Luca Lombardi},
title={PROTEINS POCKETS ANALYSIS AND DESCRIPTION},
booktitle={Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010)},
year={2010},
pages={211-216},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002725302110216},
isbn={978-989-674-019-1},
}

in EndNote Style

TY - CONF
JO - Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010)
TI - PROTEINS POCKETS ANALYSIS AND DESCRIPTION
SN - 978-989-674-019-1
AU - Cantoni V.
AU - Gatti R.
AU - Lombardi L.
PY - 2010
SP - 211
EP - 216
DO - 10.5220/0002725302110216