Prediction of Cancer using Network Topological Features

Fernanda Brito Correia, Joel P. Arrais, José Luis Oliveira

2016

Abstract

Several data mining methods have been applied to explore biological data and understand the mechanisms that regulate genetic and metabolic diseases. The underlying hypothesis is that the identification of signatures can help the clinical identification of diseased tissues. Under this principle many different methodologies have been tested mostly using unsupervised methods. A common trend consists in combining the information obtained from gene expression and protein-protein interaction networks analyses or, more recently, building series of complex networks to model system dynamics. Despite the positive results that these works present, they typically fail to generalize out of sample datasets. In this paper we describe a supervised classification approach, with a new methodology for extracting the network topology dynamics embedded in a disease system, to improve the capacity of cancer prediction, using exclusively the topological properties of biological networks as features. Four microarrays datasets were used, for testing and validation, three from breast cancer experiments and one from a liver cancer experiment. The obtained results corroborate the potential of the proposed methodology to predict a certain type of cancer and the necessity of applying different classification models to different types of cancer.

Paper Citation

in Harvard Style

Correia F., Arrais J. and Oliveira J. (2016). Prediction of Cancer using Network Topological Features . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 207-215. DOI: 10.5220/0005696202070215

in Bibtex Style

@conference{bioinformatics16,
author={Fernanda Brito Correia and Joel P. Arrais and José Luis Oliveira},
title={Prediction of Cancer using Network Topological Features},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2016)},
year={2016},
pages={207-215},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005696202070215},
isbn={978-989-758-170-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2016)
TI - Prediction of Cancer using Network Topological Features
SN - 978-989-758-170-0
AU - Correia F.
AU - Arrais J.
AU - Oliveira J.
PY - 2016
SP - 207
EP - 215
DO - 10.5220/0005696202070215