A Support Vector Machine based Prediction Model for Discrimination of Malignant Pulmonary Nodules from Benign Nodules

Yan Wu, Emmanuel Zachariah, Judith Amorosa, Anjani Naidu, Mina L. Labib, Jamil Shaikh, Donna Eckstein, Sinae Kim, John E. Langenfeld, Joseph Aisner, John L. Nosher, Robert S. DiPaola, David J. Foran

2016

Abstract

Lung cancer is the leading cause of cancer death in the United States and worldwide. Most patients are diagnosed at an advanced stage, usually stage III or IV. Identification of lung cancer patients at an early stage might enable oncologists to surgically remove the tumors. Currently, low dose CT scans are used to identify the malignant nodules in high risk patients. However, screening CT scans yield a high rate of false-positive results. A prediction model was developed for improved discrimination of malignant nodules from benign nodules in patients who underwent lung screening CT. CT images and clinical outcomes of 39 patients were obtained from the National Lung Screening Trial (NLST), National Cancer Institute, National Institute of Health. Images were analyzed to extract computational features relevant to malignancy prediction. A Support Vector Machine (SVM) based model was developed to predict the malignancy of nodules. During pilot studies, our model achieved the following prediction performance: accuracy of 0.74, sensitivity of 0.85, and specificity of 0.61.

Paper Citation

in Harvard Style

Wu Y., Zachariah E., Amorosa J., Naidu A., Labib M., Shaikh J., Eckstein D., Kim S., Langenfeld J., Aisner J., Nosher J., DiPaola R. and Foran D. (2016). A Support Vector Machine based Prediction Model for Discrimination of Malignant Pulmonary Nodules from Benign Nodules . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 129-133. DOI: 10.5220/0005824101290133

in Bibtex Style

@conference{bioimaging16,
author={Yan Wu and Emmanuel Zachariah and Judith Amorosa and Anjani Naidu and Mina L. Labib and Jamil Shaikh and Donna Eckstein and Sinae Kim and John E. Langenfeld and Joseph Aisner and John L. Nosher and Robert S. DiPaola and David J. Foran},
title={A Support Vector Machine based Prediction Model for Discrimination of Malignant Pulmonary Nodules from Benign Nodules},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING, (BIOSTEC 2016)},
year={2016},
pages={129-133},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005824101290133},
isbn={978-989-758-170-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOIMAGING, (BIOSTEC 2016)
TI - A Support Vector Machine based Prediction Model for Discrimination of Malignant Pulmonary Nodules from Benign Nodules
SN - 978-989-758-170-0
AU - Wu Y.
AU - Zachariah E.
AU - Amorosa J.
AU - Naidu A.
AU - Labib M.
AU - Shaikh J.
AU - Eckstein D.
AU - Kim S.
AU - Langenfeld J.
AU - Aisner J.
AU - Nosher J.
AU - DiPaola R.
AU - Foran D.
PY - 2016
SP - 129
EP - 133
DO - 10.5220/0005824101290133