Controlling the Cost of Prediction in using a Cascade of Reject Classifiers for Personalized Medicine

Blaise Hanczar, Avner Bar-Hen

2016

Abstract

The supervised learning in bioinformatics is a major tool to diagnose a disease, to identify the best therapeutic strategy or to establish a prognostic. The main objective in classifier construction is to maximize the accuracy in order to obtain a reliable prediction system. However, a second objective is to minimize the cost of the use of the classifier on new patients. Despite the control of the classification cost is high important in the medical domain, it has been very little studied. We point out that some patients are easy to predict, only a small subset of medical variables are needed to obtain a reliable prediction. The prediction of these patients can be cheaper than the others patient. Based on this idea, we propose a cascade approach that decreases the classification cost of the basic classifiers without dropping their accuracy. Our cascade system is a sequence of classifiers with rejects option of increasing cost. At each stage, a classifier receives all patients rejected by the last classifier, makes a prediction of the patient and rejects to the next classifier the patients with low confidence prediction. The performances of our methods are evaluated on four real medical problems.

Paper Citation

in Harvard Style

Hanczar B. and Bar-Hen A. (2016). Controlling the Cost of Prediction in using a Cascade of Reject Classifiers for Personalized Medicine . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 42-50. DOI: 10.5220/0005685500420050

in Bibtex Style

@conference{bioinformatics16,
author={Blaise Hanczar and Avner Bar-Hen},
title={Controlling the Cost of Prediction in using a Cascade of Reject Classifiers for Personalized Medicine},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2016)},
year={2016},
pages={42-50},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005685500420050},
isbn={978-989-758-170-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2016)
TI - Controlling the Cost of Prediction in using a Cascade of Reject Classifiers for Personalized Medicine
SN - 978-989-758-170-0
AU - Hanczar B.
AU - Bar-Hen A.
PY - 2016
SP - 42
EP - 50
DO - 10.5220/0005685500420050