A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells

Ming-Hsien Tsai, Ming-Jium Shieh, Cheng-Liang Peng

2016

Abstract

Many types of nano-sized anti-cancer agents that could increase efficacy of chemotherapeutic drugs have been created and developed in colon cancer treatment over years. Moreover, with the intention of achieving the ideal chemotherapeutic efficacy, nano-sized anti-cancer agents were further designed to have specific functions, efficiently killing colon cancer cells. Our research team focused on two important functions in designing nano-sized agents, controlled drug release and targeting functions. Thus, targeting functional micelles which entrapped chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38) were designed in nano-size and possessed disulfide bonds in this study. In particular, Self-Breakable SN38-loaded micelles (SN/38 micelles), Non-Breakable micelles SN38-loaded (NB/38 micelles) and Folate-targeting Self- Breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested to the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment.

Paper Citation

in Harvard Style

Tsai M., Shieh M. and Peng C. (2016). A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells . In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 216-221. DOI: 10.5220/0005766002160221

in Bibtex Style

@conference{biodevices16,
author={Ming-Hsien Tsai and Ming-Jium Shieh and Cheng-Liang Peng},
title={A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)},
year={2016},
pages={216-221},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005766002160221},
isbn={978-989-758-170-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, (BIOSTEC 2016)
TI - A Targeting Self-breakable Agent for Increased Efficacy of Chemotherapeutic Drugs against Caco2 Cells
SN - 978-989-758-170-0
AU - Tsai M.
AU - Shieh M.
AU - Peng C.
PY - 2016
SP - 216
EP - 221
DO - 10.5220/0005766002160221