DAMPING FACTOR CONSTRAINTS AND METABOLITE PROFILE SELECTION INFLUENCE MAGNETIC RESONANCE SPECTROSCOPY DATA QUANTIFICATION

M. I. Osorio Garcia, D. M. Sima, S. Van Huffel, F. U. Nielsen, U. Himmelreich

2011

Abstract

Magnetic Resonance Spectroscopy (MRS) is a technique used for the diagnostics of tumour and metabolic diseases by estimating the metabolite concentrations of the tissue under investigation. Unreliable metabolite estimation may mislead the diagnosis and therefore quantification of MRS in vivo signals must be performed carefully. In this work, we quantify 1.5 Tesla (T) and 9.4 T MRS in vivo signals and study the influence of the damping factor constraint and the metabolite profile selection used in the quantification method. The damping factor bounds the linewidth of the metabolite profiles and may yield bad fits if wrongly selected. Furthermore, MRS data quantification leads to overestimation of some metabolite concentrations when the selected metabolite basis set is incomplete suggesting that metabolites are fitting the region of their neighboring components. Here, we evaluate the normality of the residual which in cases of good fitting contains no metabolites and only white Gaussian noise. Furthermore, we propose to estimate the damping bound adaptively by taking into account information from the linewidth of the signal and the metabolite basis set.

Paper Citation

in Harvard Style

I. Osorio Garcia M., M. Sima D., Van Huffel S., U. Nielsen F. and Himmelreich U. (2011). DAMPING FACTOR CONSTRAINTS AND METABOLITE PROFILE SELECTION INFLUENCE MAGNETIC RESONANCE SPECTROSCOPY DATA QUANTIFICATION . In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011) ISBN 978-989-8425-35-5, pages 176-181. DOI: 10.5220/0003139301760181

in Bibtex Style

@conference{biosignals11,
author={M. I. Osorio Garcia and D. M. Sima and S. Van Huffel and F. U. Nielsen and U. Himmelreich},
title={DAMPING FACTOR CONSTRAINTS AND METABOLITE PROFILE SELECTION INFLUENCE MAGNETIC RESONANCE SPECTROSCOPY DATA QUANTIFICATION},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)},
year={2011},
pages={176-181},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003139301760181},
isbn={978-989-8425-35-5},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2011)
TI - DAMPING FACTOR CONSTRAINTS AND METABOLITE PROFILE SELECTION INFLUENCE MAGNETIC RESONANCE SPECTROSCOPY DATA QUANTIFICATION
SN - 978-989-8425-35-5
AU - I. Osorio Garcia M.
AU - M. Sima D.
AU - Van Huffel S.
AU - U. Nielsen F.
AU - Himmelreich U.
PY - 2011
SP - 176
EP - 181
DO - 10.5220/0003139301760181