The Possibilities of Filtering Pairs of SNPs in GWAS Studies - Exploratory Study on Public Protein-interaction and Pathway Data

Matej Lexa, Stanislav Stefanic

2014

Abstract

Genome-wide association studies have become a standard way of discovering novel causative alleles by looking for statisticaly significant associations in patient genotyping data. The present challenge for these methods is to discover associations involving multiple interacting loci, a common phenomenon in diseases often related to epistasis. The main problem is the exponential increase in necessary computational power for every additional interacting locus considered in association tests. Several approaches have been proposed to manage this problem, including limiting analysis to interacting pairs and filtering SNPs according to external biological knowledge. Here we explore the possibilities of using public protein interaction data and pathway maps to filter out only pairs of SNPs that are likely to interact, perhaps because of epistatic mechanisms working at the protein level. After filtering all possible pairs of SNPs by their presence in common protein-protein interactions or proteins sharing a metabolic or signalling pathway, we calculate the possible reduction in computational requirements under different scenarios. We discuss these exploratory results in the context of the so-called ”lost heredity” and the usefulness of this approach for similar scenarios.

Paper Citation

in Harvard Style

Lexa M. and Stefanic S. (2014). The Possibilities of Filtering Pairs of SNPs in GWAS Studies - Exploratory Study on Public Protein-interaction and Pathway Data . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014) ISBN 978-989-758-012-3, pages 259-264. DOI: 10.5220/0004915002590264

in Bibtex Style

@conference{bioinformatics14,
author={Matej Lexa and Stanislav Stefanic},
title={The Possibilities of Filtering Pairs of SNPs in GWAS Studies - Exploratory Study on Public Protein-interaction and Pathway Data},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014)},
year={2014},
pages={259-264},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004915002590264},
isbn={978-989-758-012-3},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014)
TI - The Possibilities of Filtering Pairs of SNPs in GWAS Studies - Exploratory Study on Public Protein-interaction and Pathway Data
SN - 978-989-758-012-3
AU - Lexa M.
AU - Stefanic S.
PY - 2014
SP - 259
EP - 264
DO - 10.5220/0004915002590264