Early Detection of Mild Cognitive Impairment and Mild Alzheimer’s Disease in Elderly using CBF Activation during Verbally-based Cognitive Tests

Shohei Kato, Hidetoshi Endo, Risako Nagata, Takuto Sakuma, Keita Watanabe

2014

Abstract

With the goal of promoting a fruitful and healthy longevity society, this paper presents a verbally-based cognitive task and an early detection method of dementia and mild cognitive impairment for elderly. As designed with conscious of daily conversation, the task is done by verbally responding to questionnaire. An elderly firstly talks about the topics of favorite season, travel, gourmet, and daily life, and then he/she does three cognitive tasks of reminiscence, category recall, and working memory. With the use of the functional near-infrared spectroscopy (fNIRS), which can measure cerebral blood flow activation non-invasively, we had collected 42 CHs fNIRS signals on frontal and right and left temporal areas from 22 elderly participants (7 males and 15 females between ages of 64 to 89) during cognitive tests in a specialized medical institute. All participates are classified into three clinical groups: elderly individuals with cognitively normal controls (CN), patients with mild cognitive impairment (MCI), and mild Alzheimer’s disease (AD). In this paper, we report a task effect measurement of the verbally-based cognitive task by the statistical tests of fNIRS signals, and then report the examination of the detection performance by cross-validation using proposed Bayesian classifier, which can discriminate among elderly individuals with three clinical groups: CN, MCI, and AD. Consequently, empirical result indicated that total accuracy rate is more than 95% and the result suggests that proposed approach is adequate practical to screen the elderly with cognitive impairment.

Paper Citation

in Harvard Style

Kato S., Endo H., Nagata R., Sakuma T. and Watanabe K. (2014). Early Detection of Mild Cognitive Impairment and Mild Alzheimer’s Disease in Elderly using CBF Activation during Verbally-based Cognitive Tests . In Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2014) ISBN 978-989-758-010-9, pages 366-373. DOI: 10.5220/0004821603660373

in Bibtex Style

@conference{healthinf14,
author={Shohei Kato and Hidetoshi Endo and Risako Nagata and Takuto Sakuma and Keita Watanabe},
title={Early Detection of Mild Cognitive Impairment and Mild Alzheimer’s Disease in Elderly using CBF Activation during Verbally-based Cognitive Tests},
booktitle={Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2014)},
year={2014},
pages={366-373},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004821603660373},
isbn={978-989-758-010-9},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Health Informatics - Volume 1: HEALTHINF, (BIOSTEC 2014)
TI - Early Detection of Mild Cognitive Impairment and Mild Alzheimer’s Disease in Elderly using CBF Activation during Verbally-based Cognitive Tests
SN - 978-989-758-010-9
AU - Kato S.
AU - Endo H.
AU - Nagata R.
AU - Sakuma T.
AU - Watanabe K.
PY - 2014
SP - 366
EP - 373
DO - 10.5220/0004821603660373