Bayesian Prognostic Model for Genomic Discovery in Bipolar Disorder

Swetha S. Bobba, Amin Zollanvari, Gil Alterovitz

2014

Abstract

Integrative approaches that incorporate multiple experiments have shown a potential application in the discovery of disease-related attributes. This study presents a unique, data-driven, integrative, Bayesian approach to merge gene expression data from various experiments into prognostic models and evaluate them for the discovery of bipolar-related attributes. Two prognostic models were constructed: a singlystructured Bayesian and a Bayesian multi-net model, which differentiated Bipolar disease state at a higher level of abstraction. These prognostic models were evaluated to find the most common attributes responsible for the disease and their AUROC, using external crossvalidation. The multi-net model achieved an AUROC of 0.907 significantly outperforming the single-structured model with an AUROC of 0.631. The study found six new genes and five chromosomal regions associated with the bipolar state. Enrichment analysis performed in this study revealed biological concepts and proteins responsible for the disease. We anticipate this method and results will be used in the future to integrate information from multiple experiments for the same or related phenotypes of various diseases and also to predict the disease state earlier.

Paper Citation

in Harvard Style

Bobba S., Zollanvari A. and Alterovitz G. (2014). Bayesian Prognostic Model for Genomic Discovery in Bipolar Disorder . In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014) ISBN 978-989-758-012-3, pages 91-98. DOI: 10.5220/0004642100910098

in Bibtex Style

@conference{bioinformatics14,
author={Swetha S. Bobba and Amin Zollanvari and Gil Alterovitz},
title={Bayesian Prognostic Model for Genomic Discovery in Bipolar Disorder},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014)},
year={2014},
pages={91-98},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004642100910098},
isbn={978-989-758-012-3},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2014)
TI - Bayesian Prognostic Model for Genomic Discovery in Bipolar Disorder
SN - 978-989-758-012-3
AU - Bobba S.
AU - Zollanvari A.
AU - Alterovitz G.
PY - 2014
SP - 91
EP - 98
DO - 10.5220/0004642100910098