Label-free Immobilization of Nano-particles on Silicon based Electrodes for Single-biomolecule Studies

Ch. Wenger, X. Knigge, M. Fraschke, D. Wolansky, P. Kulse, U. Kaletta, A. Wolff, W. Mehr, E.-M. Laux, F. F. Bier, R. Hölzel

2014

Abstract

Dielectrophoresis (DEP) is an established method for the spatial manipulation of microscopical particles. We demonstrate the temporal and permanent immobilization of polystyrene nanoparticles and protein molecules with sizes ranging from 4 nm to 500 nm. For this, regular arrays of silicon based nanoelectrodes were developed with tip diameters of 10 nm and 50 nm. No chemical modifications of molecules, particles or surfaces were needed. This opens up potentially important applications of DEP in biosensing and cell research.

Paper Citation

in Harvard Style

Wenger C., Knigge X., Fraschke M., Wolansky D., Kulse P., Kaletta U., Wolff A., Mehr W., Laux E., Bier F. and Hölzel R. (2014). Label-free Immobilization of Nano-particles on Silicon based Electrodes for Single-biomolecule Studies . In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014) ISBN 978-989-758-013-0, pages 176-180. DOI: 10.5220/0004888101760180

in Bibtex Style

@conference{biodevices14,
author={Ch. Wenger and X. Knigge and M. Fraschke and D. Wolansky and P. Kulse and U. Kaletta and A. Wolff and W. Mehr and E.-M. Laux and F. F. Bier and R. Hölzel},
title={Label-free Immobilization of Nano-particles on Silicon based Electrodes for Single-biomolecule Studies},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014)},
year={2014},
pages={176-180},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004888101760180},
isbn={978-989-758-013-0},
}

in EndNote Style

TY - CONF
JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2014)
TI - Label-free Immobilization of Nano-particles on Silicon based Electrodes for Single-biomolecule Studies
SN - 978-989-758-013-0
AU - Wenger C.
AU - Knigge X.
AU - Fraschke M.
AU - Wolansky D.
AU - Kulse P.
AU - Kaletta U.
AU - Wolff A.
AU - Mehr W.
AU - Laux E.
AU - Bier F.
AU - Hölzel R.
PY - 2014
SP - 176
EP - 180
DO - 10.5220/0004888101760180